A two-vehicle collision closed the A483 between Welshpool and Berriew for three hours.
Emergency services responded to the incident shortly after 11pm on Tuesday, January 14.
Paramedics, police officers and fire crews were sent to the scene near Wernllwyd Farm.
Dyfed-Powys Police advised motorists to find an alternative route.
The road re-opened at 2.05am on Wednesday, January 15.
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